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November 15, 2007

TOSHIBA ANNOUNCES ITS FOURTH GENERATION CONTRAST-FREE TECHNIQUE — TIME AND SPACE ANGIOGRAPHY (TSA)

TSA Visualizes Dynamic Blood Flow Without Contrast Offering Safer MRA Exams

TUSTIN, CA — November 15, 2007 — As the leading developer of contrast-free magnetic resonance angiography (MRA) techniques, Toshiba America Medical Systems, Inc., today introduced a fourth generation contrast-free imaging technique, Time and Space Angiography (TSA). Adding to the robust offering of contrast-free techniques from Toshiba, TSA creates images that show dynamic blood flow without using contrast agents. As the first medical imaging company to introduce advanced contrast-free MRA techniques, Toshiba is further expanding the capabilities and safety of MRA imaging.

TSA will have a variety of clinical benefits to improve both diagnostic confidence and patient care and safety. TSA builds upon the pioneering Time-Spatial Labeling Inversion Pulse technique (Time-SLIP) and is especially desirable for patients with compromised circulations and renal flow problems. It features an extremely high temporal resolution and a continually changing inversion pulse time, creating dynamic images showing blood flow in motion.

In patients with symptoms of stroke, TSA is able to show blood flow into the brain and clearly display the area being impeded, which aids physicians in faster, more accurate diagnosis. For neurologists, the use of TSA will enable the diagnosis of cerebral spinal fluid diseases non-invasively.

“We have been at the forefront of contrast-free imaging, offering our customers safe, contrast-free techniques that capture images equal to, and in many cases superior to, images captured using contrast,” said Bob Giegerich, director, MR Business Unit, Toshiba. “We are fully committed to patient safety and continue to create new contrast-free MRA techniques that are advancing the industry. As more information is disseminated about the dangers of gadolinium-based contrast agents, it is crucial to have viable contrast-free techniques available.”

Gadolinium-based contrast agents, commonly used in MRA, have been directly linked to nephrogenic systemic fibrosis, also known as nephrogenic fibrosing dermopathy (NSF/NFD), a sometimes fatal disease that occurs in patients with renal insufficiency. According to a recent study by rheumatologists at Massachusetts General Hospital¹, NSF cases could reach epidemic proportions. The study found that NSF affected 30 percent of hemodialysis patients who were exposed to gadolinium during an MR exam. Previous studies had estimated only a 2 to 5 percent incidence for developing NSF after receiving gadolinium.

Available on all Toshiba Vantage MR systems, TSA builds upon and adds to the suite of Toshiba’s proprietary, contrast-free MRA techniques including Fresh Blood Imaging (FBI), Contrast-free Improved Angiography (CIA) and Time-Spatial Labeling Inversion Pulse (Time-SLIP). More information about Toshiba’s contrast-free techniques and contrast-free clinical images can be found at www.nocontrast.com.

About Toshiba
With headquarters in Tustin, Calif., Toshiba America Medical Systems markets, sells, distributes and services diagnostic imaging systems, and coordinates clinical diagnostic imaging research for all modalities in the United States. Toshiba Medical Systems Corp., an independent group company of Toshiba Corp., is a global leading provider of diagnostic medical imaging systems and comprehensive medical solutions, such as CT, Cath & EP Labs, X-ray, Ultrasound, Nuclear Medicine, MRI and information systems. Toshiba Corp. is a leader in information and communications systems, electronic components, consumer products, and power systems. Toshiba has approximately 191,000 employees worldwide and annual sales of $60 billion. For more information, visit www.medical.toshiba.com.

¹ Hayes, Emily.” Study finds NSF more common than previously reported.”www.diagnosticimaging.com 3 October 2007.